{"publisher":"Testosterone Co","product":"Testosterone","preparedAt":"2026-11-07","reviewStatus":"Research drafts; medical review has not been claimed","facts":[{"label":"Research finding 1","text":"In TRAVERSE, the primary endpoint (cardiovascular death, nonfatal heart attack or nonfatal stroke) occurred in 7.0% on testosterone and 7.3% on placebo (hazard ratio 0.96, 95% CI 0.78 to 1.17), meeting noninferiority; mean treatment was 21.7 months and mean follow-up 33.0 months.","href":"https://pubmed.ncbi.nlm.nih.gov/37326322/"},{"label":"Research finding 2","text":"The ACP evidence review (38 RCTs of at least 6 months plus 20 observational studies) found small improvements in sexual functioning and quality of life, and little to no effect on physical functioning, depressive symptoms, energy and vitality, or cognition.","href":"https://pubmed.ncbi.nlm.nih.gov/31905375/"},{"label":"Research finding 3","text":"In the Testosterone Trials, testosterone significantly increased sexual activity, sexual desire and erectile function and slightly improved mood and depressive symptoms, but had no significant benefit on vitality (fatigue scale).","href":"https://pubmed.ncbi.nlm.nih.gov/26886521/"},{"label":"Research finding 4","text":"A network meta-analysis of 29 placebo-controlled RCTs (3,393 men) found every testosterone form raised mean hematocrit; intramuscular enanthate/cypionate raised it 4.0% (95% CI 2.9 to 5.1), significantly more than the patch.","href":"https://pubmed.ncbi.nlm.nih.gov/34445892/"},{"label":"Research finding 5","text":"The current Depo-Testosterone label states that safety and efficacy in men with age-related (late-onset) hypogonadism have not been established; a generic cypionate label revised June 2026 carries the same statement.","href":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cfbb53d4-b868-4a28-8436-f9112eb01c39"}],"sources":[{"title":"Depo-Testosterone (testosterone cypionate) prescribing information","href":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cfbb53d4-b868-4a28-8436-f9112eb01c39"},{"title":"Endocrine Society 2018 guideline: testosterone therapy in men with hypogonadism","href":"https://pubmed.ncbi.nlm.nih.gov/29562364/"},{"title":"American College of Physicians 2020 guideline on testosterone treatment","href":"https://pubmed.ncbi.nlm.nih.gov/31905405/"},{"title":"TRAVERSE: cardiovascular safety of testosterone replacement therapy","href":"https://pubmed.ncbi.nlm.nih.gov/37326322/"},{"title":"FDA: testosterone information for patients and providers","href":"https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/testosterone-information"},{"title":"FDA: human drug compounding","href":"https://www.fda.gov/drugs/guidance-compliance-regulatory-information/human-drug-compounding"}],"guides":[{"title":"Blood tests during testosterone treatment: what gets checked and why","url":"https://testosteroneco.com/research-guides/blood-tests-on-treatment","description":"What labels and guidelines say about testosterone, hematocrit, prostate and blood pressure checks before and during testosterone treatment.","date":"2026-11-09"},{"title":"Testosterone cypionate: what the FDA label says","url":"https://testosteroneco.com/research-guides/cypionate-label-what-it-says","description":"What the testosterone cypionate label says about the drug, its approved uses, dosing range, contraindications, warnings and side effects.","date":"2026-11-09"},{"title":"Heart, clots and blood pressure: what the trials and labels measured","url":"https://testosteroneco.com/research-guides/heart-clots-and-blood-pressure","description":"What TRAVERSE, FDA actions from 2015 and 2025, and testosterone labels say about heart events, blood clots and blood pressure.","date":"2026-11-09"},{"title":"How low testosterone is diagnosed, and why two morning tests matter","url":"https://testosteroneco.com/research-guides/how-low-testosterone-is-diagnosed","description":"How guidelines and the cypionate label describe diagnosing low testosterone: fitting symptoms plus repeat morning blood tests.","date":"2026-11-09"},{"title":"How to read a testosterone study: who was enrolled and what was measured","url":"https://testosteroneco.com/research-guides/how-to-read-a-testosterone-study","description":"Use TRAVERSE, the Testosterone Trials, T4DM and the ACP review to see how enrollment and endpoints shape what a study shows.","date":"2026-11-09"},{"title":"Injection, cream and gel: how testosterone forms differ","url":"https://testosteroneco.com/research-guides/injection-cream-and-gel-differences","description":"How testosterone cypionate injection, testosterone gel and compounded cream differ in use, skin transfer, regulation and blood counts.","date":"2026-11-09"},{"title":"Questions to bring to your provider visit","url":"https://testosteroneco.com/research-guides/questions-for-your-provider","description":"Questions on diagnosis, safety, dose and monitoring to bring to a testosterone visit, each tied to what the label or guideline says.","date":"2026-11-09"},{"title":"Symptoms of low testosterone that other conditions can explain","url":"https://testosteroneco.com/research-guides/symptoms-and-other-causes","description":"Low testosterone symptoms are nonspecific. See what the sources say about other causes and why one blood test is not enough.","date":"2026-11-09"},{"title":"Testosterone and fertility: what to know before starting","url":"https://testosteroneco.com/research-guides/testosterone-and-fertility","description":"What labels, guidelines and research say about testosterone treatment, sperm production and recovery for men who may want children.","date":"2026-11-09"},{"title":"What the Testosterone Trials and the T4DM trial found","url":"https://testosteroneco.com/research-guides/testosterone-trials-and-t4dm","description":"What two placebo-controlled testosterone trials measured: sex, mood, energy, bone, plaque, blood sugar and hematocrit.","date":"2026-11-09"},{"title":"What the TRAVERSE trial tested, and what it did not","url":"https://testosteroneco.com/research-guides/traverse-trial-what-it-tested","description":"TRAVERSE tested a daily testosterone gel in 5,246 men with heart risk. Here is what it found on heart events, clots, rhythm and fractures.","date":"2026-11-09"},{"title":"What \"compounded\" testosterone means and does not mean","url":"https://testosteroneco.com/research-guides/what-compounded-testosterone-means","description":"Compounded testosterone is not FDA approved. Here is what FDA says that means, and how an approved cypionate label compares.","date":"2026-11-09"}]}